Wortmannin
MERCK相關(guān)產(chǎn)品資料：
681675 Wortmannin ( Wortmannin )
KY 12420
A cell-permeable, fungal metabolite that acts as a potent, selective, and irreversible inhibitor of phosphatidylinositol 3-kinase in purified preparations and cytosolic fractions (IC50 = 5 nM). Blocks the catalytic activity of PI 3-kinase without affecting the upstream signaling events. Preincubation of fibroblasts with wortmannin abolishes PDGF-mediated Ins(3,4,5)P3 formation (IC50 = 5 nM). Also blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Inhibits MAP kinase activation induced by platelet activating factor in guinea pig neutrophils (200 - 300 nM). Also inhibits other kinases such as myosin light chain kinase (IC50 = 200 nM) and PI 4-kinase at concentrations higher than that required for inhibition of PI 3-kinase. Also blocks phospholipase D. A 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681676) in DMSO is also available.
Product number
型號
價格
681675-1MG
1 mg
詢價
產(chǎn)品信息
Form
White to off-white solid
Primary Target
phosphatidylinositol-3-kinase
Primary Target IC50
5 nM
Secondary target
mlck (IC,sub>50 = 200 nM)
Molar mass
428.4
Protect from Light
Yes
Packaged under inert gas
Cell permeable
Purity
≥95% by HPLC
Solubility
DMSO or MeOH
Chemical formula
C23H24O8
RTECS
CB9641000
CAS number
19545-26-7
Merck USA index
14, 10053
Store and ship information
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
-20°C
Ship
Ambient Temperature Only Highly Toxic
**標(biāo)示
S Phrase
S: 22-36/37/39-45 Do not breathe dust. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
R Phrase
R: 26/27/28
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