產(chǎn)品名稱：soluble α-Klotho human ELISA 產(chǎn) 地：Demeditec 產(chǎn)品貨號：JP27998 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說明： Special remarks: INTRODUCTION “α-klotho” was identified as an extremely down-regulated gene in the genetically-modified mouse of which phenotype is very similar to various symptoms of human aging. Then, the sequences of α-klotho genes have been identified in various species including humans based on the one of mouse. α-Klotho protein is a 130 kDa, one-transmembrane protein and its expression is confirmed in the kidneys and the parathyroid glands. In recent years, it has become clear that α-Klotho is an important molecule within a living organism regulating the metabolism of mineral such as calcium and phosphorus. Therefore, it is considered that, in α-klotho mouse, early aging-like symptoms are induced by impaired mineral homeostasis caused by decreased expression of α-Klotho. Meanwhile, it is reported that the long N-terminal extracellular domain which comprises the major portion of sequence of α-Klotho protein is released free into blood by shedding. However, there are many unclear points about functions and changes in concentration of free (soluble) α-Klotho protein, so it has been required to develop the measurement system of α-Klotho. This ELISA kit can measure Human soluble α-Klotho protein in human blood. PRINCIPLE This kit is a solid phase sandwich ELISA using 2 kinds of highly specific antibodies. Tetra Methyl Benzidine (TMB) is used as a coloring agent (Chromogen). The strength of coloring is proportional to the quantities of Human soluble α-Klotho. 上海玉博生物技術有限公司在為生命科學領域提供豐富的產(chǎn)品與信息資源方面處于國內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個國家近五十萬種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長和更新，公司提供的產(chǎn)品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質(zhì)組學研究的認知，以及分子診斷和臨床醫(yī)學領域的應用。
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