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產品名稱:Prolactin canine ELISA
產 地:Demeditec
產品貨號:DEV9944
產品規(guī)格:96 Tests
產品說明:
Special remarks:
Canine prolactin (cPRL) is a single-chain polypeptide hormone of the canine anterior pituitary with a molecular mass of approx. 22,000. Prolactin from different species exhibits significant variations in the amino acid sequence. Canine prolactin differs from human prolactin at about 60 percent of all residues.
The secretion of cPRL from the pituitary is inhibited by hypothalamic prolactin-inhibitory factor (PIF). Although dopamine was long thought to be this PIF molecule, today it seems that there is a special peptide with prolactin-inhibiting activities. The release of prolactin is certainly stimulated by different peptides, particularly thyrotropin releasing hormone (TRH) and vasocative intestinal peptide (VIP). Estrogens and progesterone also seem to play a role in the secretion of prolactin, and neurogenic factors influence its release. Milking and suckling are immediately followed by an increase in serum cPRL.
The most important role of prolactin is stimulation of mammary gland growth and lactation. During pregnancy, prolactin levels in canine blood increase slightly; during lactation, significantly. Prolactin has a wide variety of other physiological actions. It affects water and electrolyte balance, metabolism and gonadal function; is an important stress hormone; and seems to play a role in the maintenance of the long interestrous interval in the bitch.
In dogs with pituitary-depent hyperadrenocorticism, prolactin levels in blood were higher than in healthy animals. Prolactin determinations can be used in the therapeutic control of hyperprolactinemia. During a pseudo pregnancy, prolactin is increased. Therapy with alkaloids like bromocriptine lowers PRL levels, and lactation and maternal behaviour are decreased.
The secretory capacity of the pituitary can be tested with the TRH stimulation test.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于國內**地位,公司提供的產品涵蓋了二十多個國家近五十萬種產品,而且產品的數(shù)量與信息在不斷的增長和更新,公司提供的產品能夠使生命科學工作者加快對生物化學,分子生物學,細胞生物學以及蛋白質組學研究的認知,以及分子診斷和臨床醫(yī)學領域的應用。