產(chǎn)品名稱：Estrone RIA 產(chǎn) 地：Demeditec 產(chǎn)品貨號(hào)：DEKIPI9100 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說明： Special remarks: 1.INTENDED USE For IN VITRO determination of serum or plasma ESTRONE levels. The origin of plama estrogens in the femal have been precisely studied by refined isotopic dilution techniques. In normal women, most plasma estradiol is derived from the ovary, where theca cells secrete androstenedione, which is then converted to estrone and then to estradiol by the granulosa cells. Little estrone is indeed formed and secreted by the ovary : most originates from a peripheral conversion of estradiol and from the aromatisation of androstenedione, a catalytic reaction essentially carried out in adipose tissue. In premenopausal women, androstenedione is secreted by the ovary and the adrenals. In pregnant women, the fetal adrenal gland provides a significant contribution to androstenedione production. In menopausal women, estrone is the essential estrogen found in the circulation, resulting from the conversion of adrenal androstenedione. An increase in estrogen formation occurs with aging and in correlation with the amount of adipose tissue. The estrogenic effects of estrone in menopausal women can produce endometrial hyperplasia and bleeding but also maintains the bone mineral content. In premenopausal women, excessive estrone blood levels can result from the conversion of large amounts of androstenedione produced in micropolycystic ovary syndrome and ovarian tumors. In such women, high estrone blood levels can participate in a disturbance of the menstrual cycle. Estrone in the circulation is essentially bound to albumin. This is important in the interpretation of estrone-assay data. Indeed, and contrary to estradiol, total estrone levels are not significantly modified by SHBG concentration. 2.PRINCIPLE OF THE METHOD Since the concentrations of 125I - E1 and coated antibodies are constant, the advancing state of the equation depends on the concentration of E1. The amount of 125I - E1 bound to the coated tube is inversely proportional to the concentration of E1 in the sample. Following the incubation, the tube is washed to remove excess of unbound labelled. Patient samples concentration are read from a calibration curve. 上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于國(guó)內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個(gè)國(guó)家近五十萬種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長(zhǎng)和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對(duì)生物化學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認(rèn)知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。
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