產(chǎn)品名稱：PMN Elastase ELISA
產(chǎn)    地：Demeditec 
產(chǎn)品貨號：DEH3311
產(chǎn)品規(guī)格：96 Tests
產(chǎn)品說明：
Special remarks:
The human organism reacts with an inflammatory response to attacks of invading pathogens (micro-organisms  and  viruses)  or  damaged  tissue  (after  accidents  or  surgery).  Polymorphonuclear  (PMN) granulocytes  play  an  important  role  as  primary  defence  cells  in  this  inflammatory  reaction.  Different bloodstream mediators (cytokines, leukotrienes, complement factors, bacterial endotoxins, clotting and fibrinolysis factors) attract and stimulate these cells to phagocytize and destroy not naturally occurring agents.
PMN granulocytes use proteinases to digest these agents and tissue debris. One of these proteinases is PMN elastase which is localised in the azurophilic granules of the polymorphonuclear granulocytes.
During  phagocytosis  of  foreign  substances  these  enzymes  are  also  partially  excreted  into  the extracellular surrounding,  where the activity of PMN  elastase is regulated  by inhibitors (esp. the  α1 -proteinase  inhibitor,  α1 -PI).  An  overwhelming  release  of  PMN  elastase,  however,  can  exceed  the inhibitory  potential  of  the  α1 -proteinase  inhibitor.  Thus,  enzymatically  active  PMN  elastase,  together with simultaneously produced oxidants (O 2 -radicals, H 2 O 2 , OH-radicals), can cause local tissue injury.
Due  to  the  bloodstream  and  lymphatic  system,  however,  α1 -PI  is  delivered  subsequently  and eventually able to form a complex with all excreted elastase. Therefore, the concentration of the PMN elastase/α1 -PI complex correlates with the released PMN elastase and can be used as a measure for the activity of granulocytes during an inflammatory response.
Primarily, determinations of PMN elastase find its application in observation of the course of trauma, shock  and  sepsis.  Further  indications  are  the  areas  of  hemodialysis,  infections  by  obstetrics,  joint diseases,  effusions  of  sport  injuries,  intestinal  affection,  pancreatitis,  cystic  fibrosis  and  male  adnex affections.
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