產(chǎn)品名稱：25(OH) Vitamin D3 RIA 產(chǎn) 地：Demeditec 產(chǎn)品貨號(hào)：DEKIP1961 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說明： Special remarks: Physiological function of 25OH-Vit.D3. 25-Hydroxyvitamin D3 (25OHD3) is the trivial name of 9, 10-secocholesta-5, 7, 10(19)-triene-3b, 25-diol. This secostroid is produced in the liver by 25-hydroxylation of cholecalciferol or Vitamin D3. 25OHD3 is a precursor for other Viamin D metabolites and has only a limited biologiccal activity in itself. The most active derivative is 1a,25-Hydroxyvitamin D3, produced in the kidney (or placenta) by 1a-hydroxylation of 25OHD3. This hormonally regulated steroid stimulates the intestinal absorption of both calcium and phosphorus. It also stimulates bone resorption and mineralization thereby preventing the development of rickets or osteomalacia. This Vitamin D hormone might also be active in other tissues responsible for calcium transport (placenta, kidney, mammary gland,..) and endocrine glands (beta-cells, parathyroid glands, ...), 25-hydroxyvitamin D3 is a main precursor for the metabolites. Regulatory mechanism The production of 25-hydroxyvitamin D mainly occurs in the liver although other tissues (intestine, kidney) might perform the same hydroxylation. Although there might be some feed-back inhibition of 25-hydroxyvitamin D on its own production, a higher substrate availability (Vitamin D3) results in higher 25-hydroxyvitamin D production and higher circulating 25-hydroxyvitamin D concentrations in blood. No hormonal or other regulatory mechanism for its synthesis have been clearly identified. Clinical application for 25OH-Vit.D3 Assay This assay is of importance for the diagnosis of Vitamin D deficiency or intoxication 上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于國(guó)內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個(gè)國(guó)家近五十萬種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長(zhǎng)和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對(duì)生物化學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認(rèn)知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。
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