產(chǎn)品名稱：FSME (TBEV) IgG ELISA 產(chǎn) 地：Demeditec 產(chǎn)品貨號：DEFSM01 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說明： Special remarks: The DEMEDITEC TBEV IgG Antibody ELISA Test Kit has been designed for the the detection and the quantitative determination of specific IgG antibodies against TBEV in serum and plasma. The infection with TBEV (tick-borne encephalitis virus) occurs predominantly in early summer through the bite of a tick, infected with TBEV. Ticks can become infected during any stage of their metamorphosis and transmit the virus diaplacentally. It is assumed that the virus hibernates in the tick or other vertebrates like porcupines, dormice, bats and deer. The incubation time ranges from 4 - 21 days. The viruses were earlier called arboviruses (arthropod-borne viruses) and are combined by their function into a group of infectious pathogens, being transmitted between vertebrates by the bite of blood-sucking arthropods. These viruses replicate in the organs of the receiving arthropods, without causing symptoms of a disease or tissue damage. The cyclus vertebrate-arthropod-vertebrate is kept alive by this vector which becomes life-long infectious through the blood-sucking of a vertebrate in the viraemic phase. Today, TBEV is allocated to the group of flaviviruses. Serologically, TBEV belongs to flavivirus group B. The pathogens consist of a single strand RNA and are inactivated by ether and sodium desoxycholate. The virus can be multiplied in the brain of newborn mice, but also in cell cultures (BHK-21 and Vero cells). The viral replication takes place in the cytoplasma of infected cells. The virions form in the Golgi region. The particle size of the viruses is 80 - 100 nm. The viruses are transmitted by the tick Ixodes ricinus. Characteristic for the disease is an involvement of the bulbary or cervical sections of the spinal marrow as well as the development of ascending paralysis or hemiparesis. The occurence of residual paraplegia after the infection is not uncommon. Typical infections show a two-stage course of the disease: the first phase comes along with an uncharacteristic feverish infect with strong headaches, the second phase with a meningo-encephalitis with or without pareses. After an incubation time of 3 - 28 days (depending on the dosis of the infection), the initial phase develops with unspecific grippal symptoms. 3 - 7 days later, the symptoms decrease or, in approximately 10% of the cases, the second stage of the disease develops, marked by a renewed increase of temperature, headache, pain in the limbs and meningo-encephalitic symptoms. Paralysis in the scapular area may occur. A few days later, a stage of improvement starts which generally lasts 1 - 3 weeks. If the CNS is involved, residual damage occurs in about 7% of the cases, letality is around 1%. The clinical picture of TBEV is uncharacteristic, thus, a serological laboratory diagnosis is required. The diagnosis of a fresh infection is done by the detection of specific IgM antibodies. TBEV-specific IgG antibodies are determined for two reasons: a.) to monitor the course of the disease after infection with the TBEV (significant titer changes) b.) to determine the „immune status“ after an „active immunization“ (vaccination protection) The enzyme immunoassay for the detection of TBEV is highly sensitive and allows the determination of TBEV-specific antibodies in patient sera. 上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于國內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個(gè)國家近五十萬種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對生物化學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認(rèn)知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。
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