產(chǎn)品名稱：Mouse Adiponectin ELISA 產(chǎn) 地：Demeditec 產(chǎn)品貨號(hào)：DEE091M 產(chǎn)品規(guī)格：96 Tests 其它產(chǎn)品： Adiponectin rat Demeditec DEE091R 96 Tests 7018 產(chǎn)品說明： Special remarks: Intended Use Measurement of Adiponectin in Mouse serum and plasma samples. Introduction Adiponectin was described for the first time in the early 90th of the last century as an endocrine factor produced by adipocytes. Adiponectin is involved in regulation of energy- and fat metabolism. So its concentration in the circulation is said to reflect the risk of atherosclerosis and the degree of insulin resistance. Based on the high incidence of these diseases, adiponectin was and still is object of intensive research regarding the underlying biological mechanisms and regarding its value as biomarker. Beside different cell culture models and studies with human patients, mice and rats are suitable model organisms for basic research and pre-clinical studies. Therefore we developed and validated this testsystem as a tool for adiponectin measurements in mice usable in research and pre-clinical studies. Even if the comparability of mice and humans is limited we offer some background information on human adiponectin physiology in the following section: Adiponectin is a 30kDa protein which percentage in serum proteins is 0.01%. It is mainly synthesized by adipocytes, but also muscle cells and hepatocytes have the ability to synthesize Adiponectin. Until now, IGF-I is the only known natural inductor of the synthesis. It consists of a Collagen-like N-terminal and a globular C-terminal domain. In vivo Adiponectin appears with different oligomers. Beside the trimer and ditrimer also high molecular multimers exist. Up to now two different receptors are known, both receptors are ubiquitary expressed, though the distribution in the tissues varies. The Adiponectin Receptor 1 (AdipoR1) is especially in muscleand AdipoR2 in liver tissue synthesized. The significance for the organism is not clear until now. First studies show, that adiponectin correlates negatively with BMI and thus it could have relevance for the energy metabolism for example through the regulation of fatty acid oxidation. Beside the correlation with BMI, Adiponectin level is associated with the Insulin-Resistance and so also linked with Type II Diabetes. Adiponectin is associated also with glucose- und lipometabolism. Furthermore it is involved in inflammatory processes and therewith it is of importance for appearance of arteriosclerosis and coronay disease, thus the determination of Adiponectin level in plasma could serve to estimate the risk of coronary disease. Beside this Adiponectin influences further physiological processes as for example the angiogenesis. 上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于國(guó)內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個(gè)國(guó)家近五十萬(wàn)種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長(zhǎng)和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對(duì)生物化學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認(rèn)知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。
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