產(chǎn)品名稱：Histone Ab ELISA 產(chǎn) 地：Demeditec 產(chǎn)品貨號(hào)：DE7670 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說明： Special remarks: NAME AND INTENDED USE Histone Ab is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies to histone in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of Systemic Lupus Erythematosus (SLE) or lupus-like disorders. SUMMARY AND EXPLANATION OF THE TEST All of the nucleic acids (DNA) of eukaryotic cells is associated with proteins. The complex structure of DNA and its associated small basic proteins, which are called histones is known as chromatin. Both, The histones comprises about 50 percent of the total mass of eukaryotic chromosomes. The complex of DNA and the histones can be dissociated by treatment of the eukaryotic chromatin with salt or diluted acids. Five different types of histones are known. The are called H1, H2A, H2B, H3 and H4. Their molecular weights range from 11 to 21 kD. In correlation to their fundamental function in the organisation of chromatin, the structure of all histones in all eukaryotes is highly conserved. They contain a lot of basic amino acid residues which presumably interact with the negative charged groups of DNA. Furthermore they contain apolar amino acid residues which may be important for their interaction among each other. Antibodies to histones usually produce a homogeneous, rim or speckled pattern of nuclear staining in indirect immunoflourescence. Antibodies against the histones dimers H2A-H2B are observed within 20 to 50 percent in spontaneous systemic Lupus erythematodes and in 50 to 90 percent in procainamide induced SLE. Compared to other autoantibodies anti-histone antibodies are relatively rare in spontaneous SLE. Autoantibodies to histones are not specific for SLE but are found also in drug induced LE and rheumatoid arthritis (RA). In drug induced LE histone antibodies are found in a three times higher incidence than in SLE. Most of the anti-Histone antibodies in drug induced LE are of temporary character. They mainly disappear within a few month after treatment with the inducing drug. Determination of anti-histone antibodies is indicated in: drug induced Lupus (mainly after treatment with Procainamide, Isoniazide or Hydralazine) drug induced ANA without clinical SLE symptoms spontaneous Systemic Lupus erythematodes ANA positive and seropositive rheumatoid arthritis ANA positive sclerodermia 上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于國內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個(gè)國家近五十萬種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長(zhǎng)和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對(duì)生物化學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認(rèn)知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。
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