產(chǎn)品名稱：Rheumatoid Factor IgA ELISA
產(chǎn)    地：Demeditec 
產(chǎn)品貨號：DE7630
產(chǎn)品規(guī)格：96 Tests
其它產(chǎn)品：
Rheumatoid Factor IgG Demeditec DE7640 96 Tests 2288
Rheumatoid Factor IgM Demeditec DE7650 96 Tests 2288
產(chǎn)品說明：
Special remarks:
NAME AND INTENDED USE
Rheumatoid  Factor  IgA  is  an  indirect  solid  phase  enzyme  immunoassay  (ELISA)  for  the quantitative  measurement  of  IgA  class  rheumatoid  factor  antibodies  in  human  serum  or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of rheumatoid arthritis (RA).
SUMMARY AND EXPLANATION OF THE TEST
The presence of IgM Rheumatoid Factor (RF) in the serum is the sole serological indicator included in the ACR list of criteria for the diagnosis of RA. RFs are a subset of antiglobulins directed against the Fc region of IgG. We do not include in this definition antibodies to the IgG Fab region and pepsin agglutinators, directed against neoantigens on IgG exposed by pepsin cleavage. It is claimed that the majority of antiglobulin activity in normal serum is Fab-specific, whereas antiglobulin from RA patients is mostly Fc-specific. RFs are present in the serum of 75-80% of patients with RA at some time during the disease course.
However, RFs are  also  found  in  the  serum  of  patients  with  infectious  and  autoimmune  diseases,  hyperglobulinemias, B-cell lymphoproliferative disorders and in the aged population. This suggests that RF may be a finding associated with B-cell hyperactivity.
Rheumatoid Factors which have been found among the IgM, IgG and IgA classes of immunoglobulins, reacting only with xenogeneic Fc are not autoantibodies and are unlikely to be of pathological significance. However, RFs can bind IgG from many species, including autologous IgG, when immobilized on surfaces. Autologous binding is of higher affinity than xenogeneic binding. The here presented test systems for the deter-mination of rheumatoid factors uses only human Fc-fragments as coated antigen.
It is generally considered that high titer RFs are associated with more severe disease and the  presence  of  extra-articular  features  and  rheumatoid  nodules.  This  conclusion  may  depend on the disease duration. Serum IgM RF may precede the onset of RA by several years.
A high titer of RF in non-RA individuals is associated with increased risk of developing RA. In the first 2 years of RA (early RA), serum levels of IgM, IgG and IgA RF do not correlate with disease  activity.  Serum IgG  and IgA  RF  in these  years  are  prognostic of  erosive  joint  disease.
In established RA, high titer serum IgM RF correlates with the presence of articular disease and nodules but not with systemic disease activity. The presence of either IgG or IgA RF in patients  with  long-standing  RA  may  be  a  good prognostic  indicator  of  systemic  manifestations. IgG and IgM RF are associated with extra-articular RA including rheumatoid vasculitis and nodules. The presence of IgM RF - containing immune complexes with bound complement (C1q) - is also associated with extra-articular RA.
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