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產(chǎn)品名稱：Thyreoidal Peroxidase Ab (TPO-Ab) 產(chǎn) 地：Demeditec 產(chǎn)品貨號(hào)：DE7580 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說(shuō)明： Special remarks: Thyreoidal Peroxidase Ab (TPO-Ab) is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies against thyroid peroxidase (TPO) in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of Hashimoto´s Thyroiditis. Thyroid disorders are the most prevalent of all autoimmune diseases. Thyroid autoimmune diseases are associated with the occurence of differentiated autoantibodies and are thought to be related to a genetical pre-disposition. These autoantibodies are directed against membrane-located and/or extracellular antigens of the thyroid cells.: -Thyroglobulin (hTg), a water soluble glycoprotein with a molecular weight of approx. 660.000 Dalton, is the principal constituent of the thyroidal colloid sharing about 75 % of it's mass. Synthesis of the thyroid hormones T3 and T4 is based on the oxidative iodination of thyrosine residues of the thyroglobulin molecule. Within the cell thyroglobulin is trans-ported by the microsomes. Together with the secretion of T3 and T4 also small amounts of hTg are liberated into circulation. -The microsomal antigen of the thyroid is an integral membrane protein of the microsomes. It has been characterized as the enzyme Thyroid Peroxidase (TPO) with a molecular weight of nearly 110.000 Dalton. -The TSH-Receptor is a regulatory protein enbedded into the thyroid cell membrane effecting synthesis and release of the thyroid hormones as well as cellular growth. -The so-called Colloid-Antigen 2 CA2. Besides these antibodies to functional antigens, antibodies directed against the circulating thyroid hormones T3 und T4 may occur. In Graves' Diseases, an immunogenetic form of hyperthyroidism often additional antibodies occur, which are directed against eye muscle antigens. They cause the endocrine ophalmopathy. Autoantibodies are found in inflammatory disaeses as well as in thyroid autoimmune disorders. Various symptoms of thyroid diseases, like goiter, thyroid pain, hyperthyroidism and hypothyroidism may be caused by immunogenetic processes and the occurence of organ specific antibodies. This underlines the clinical relevance for autoantibody determination for the assesment of thyroid diseases. Most important autoimmune diseases of the thyroid gland are: Hashimoto's Thyroiditis Primary Myxedema Graves' disease (often associated with endocrine ophtalmopathy) and other asymptomatic, for example postpartum thyroiditis. The occurence of Anti-TG and Anti-TPO autoantibodies at the same time seem to be related to their functional association. Thyrosine amino acid residues of the thyroglobulin molecule, as primary protein for the synthesis of the thyroid hormones T3 and T4, are actively iodinated in association with the thyroid peroxidase (TPO). TSH acts in stimulating synthesis and release of thyroid hormones in close cooperation of all the proteins. This makes the simultaneous appearance of all these antibodies plausible. Persisting inhibition of the peroxidase activity by specific autoantibodies (Anti-TPO Ab's) causes a decrease in the synthesis of thyroid hormones and thus hypothyroidism. Especially at the end of pregnancy, determination of thyroid antibodies may be a helpful diagnostic tool in the early diagnosis of an onset of post-partum hypothyroidism (Hashimoto's post partum depression). Hashimoto diseases are often associated with highly elevated titers of thyroid autoantibodies. The concentration of antibodies against thyroglobulin exceeds the titer of Anti-TPO antibodies, whereas in Graves' disease the opposite situation is found, with a stronger elevation of the Anti-TPO antibodies. Additionally, also high concentrations of TSH receptor antibodies is characteristic for both diseases. 上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于國(guó)內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個(gè)國(guó)家近五十萬(wàn)種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長(zhǎng)和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對(duì)生物化學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認(rèn)知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。
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