產(chǎn)品名稱：Interleukin-6 rat ELISA
產(chǎn)    地：Demeditec 
產(chǎn)品貨號(hào)：DE4845
產(chǎn)品規(guī)格：192 Tests
產(chǎn)品說(shuō)明：
Special remarks:
Interleukin-6 (IL-6) is a multi-functional cytokine that regulates immune responses, acute phase reactions and hematopoiesis and may play a central role in host defense mechanisms.
IL-6 is usually not produced constitutively by normal cells, but its expression is readily induced by a variety of cytokines, lipopolysaccharide or viral infections.
IL-6 is a pleiotropic cytokine produced by a variety of cells. It acts on a wide range of tissues, exerting growth-induction, growth-inhibition, and differentiation respectively, depending on the nature of the target cells.
IL-6 is involved in
-the induction of B-cell differentiation,
-the induction of acute phase proteins in liver cells,
-growth promotion of myeloma/plasmacytoma/hybridoma cells,
-induction of IL-2 and IL-2 receptor expression,
-proliferation and differentiation of T cells,
-inhibition of cell growth of certain myeloid leukemic cell lines and induction of their differentiation to macrophages,
-enhancement of IL-3-induced multipotential colony cell formation in hematopoietic stem cells and induction of maturation of megakaryocytes as a thrombopoietic factor,
-induction of mesangial cell growth,
-induction of neural differentiation of PC 12 cells and
-induction of keratinocyte growth
The abnormal production of IL-6 was first suggested to be related to polyclonal B-cell activation with autoantibody production in patients with cardiac myxoma. Since then, IL-6 has been suggested to be involved in the pathogenesis of a variety of diseases. Measurement of IL-6 levels in serum and other body fluids thus provides more detailed insights into various pathological situations.
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