產(chǎn)品名稱：CA 15-3 IRMA 產(chǎn) 地：Demeditec 產(chǎn)品貨號：DE4426 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說明： Special remarks: CLINICAL BACKGROUND Biological activities The CA 15-3 antigen is a high-molecular-weight mucin glycoprotein termed MUC-1. It has been characterized with monoclonal antibodies developed against purified extracts of a membrane fraction isolated from a human breast carcinoma (clone DF3) and against human milk fat globule membrane (clone 115D8). Other names for the mucin include polymorphic epithelial mucin (PEM), epithelial membrane antigen (MEA) or episalin. Clinical applications This marker is most useful in evaluating the effect of treatment for women with advanced breast cancer. Elevated levels of CA15-3 are also associated with cancers of the ovary, lung and prostate, as well as non-cancerous conditions such as benign breast or ovarian disease, endometriosis, pelvic inflammatory disease and hepatitis. Pregnancy and lactation also can raise CA 15-3 levels. PRINCIPLES OF THE METHOD The Demeditec CA 15-3-IRMA is a two-step immunoradiometric assay based on coated?tube separation. Mab1, the capture antibody, is attached to the lower and inner surface of the plastic tube. Add calibrators or samples to the tubes. After incubation, washing removes the occasional excess of antigen. Addition of Mab2, the signal antibody labelled with 125I, will complete the system and trigger the immunological reaction. After washing, the remaining radioactivity bound to the tube reflects the antigen concentration. 上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于國內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個國家近五十萬種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對生物化學(xué)，分子生物學(xué)，細胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。
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