產(chǎn)品名稱：NSE IRMA 產(chǎn) 地：Demeditec 產(chǎn)品貨號(hào)：DE4411 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說(shuō)明： Special remarks: CLINICAL BACKGROUND Biological activities The glycolytic enzyme enolase (2-phospho-D-glycerate hydrolase, EC 4.2.1.11) exists as several dimeric isoenzymes (aa, ab, ag, bb and gg). The gg and ag enolase isoenzymes are also known as neuron- specific enolase (NSE) as they are produced in central and peripheral neurons and malignant tumors of neuroectodermal origin. Elevated serum concentrations of NSE are detected in patients with medullar carcinoma of the thyroid, pancreatic islet cell tumor, pheochromocytoma carcinoid, neuroblastoma and small-cell lung carcinoma (SCLC). Clinical applications The diagnosis of lung cancer generally requires medical imaging, endoscopy, intra-operative findings and histology. An important indication for tumor marker determinations in lung cancer is in assessing the efficacy of therapy and post-operative follow-up care. In patients with SCLC, serum levels of NSE reflect the response to chemotherapy. PRINCIPLES OF THE METHOD The Demeditec NSE-IRMA is an immunoradiometric assay based on coated-tube separation. Mab1, the capture antibody, is attached to the lower and inner surface of the plastic tube. Calibrators or samples added to the tubes will at first show low affinity for Mab1. Addition of Mab2, the signal antibody labelled with 125I, will complete the system and trigger the immunological reaction. After washing, the remaining radioactivity bound to the tube reflects the antigen concentration. 上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于國(guó)內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個(gè)國(guó)家近五十萬(wàn)種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長(zhǎng)和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對(duì)生物化學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認(rèn)知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。
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