產(chǎn)品名稱：Cystatin C (rat) ELISA 產(chǎn) 地：Demeditec 產(chǎn)品貨號：DE391009200R 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說明： Special remarks: Introduction Cystatin C is a mammalian cysteine protease inhibitor, synthesized in various levels by different cell-types and appears in most body fluids. Cystatin C has nothing to do with the statin drugs that are used to lower cholesterol. It is also known as cystatin 3 and CST3. Cystatins belong to a superfamily of cysteine proteases inhibitors such as papain and Cathepsins B, H, K, L, and S. They have been found in both plants and animals. Cystatin C, with molecular weight of 13 260 Da and composed of 120 amino acids, lacks carbohydrate and contains two disulfide bridges located near the carboxyl terminus. Cystatin C was identified, quantitated, and localized in mouse, rat, and human retinas. In the normal ***** rat retina Cystatin C is present at high concentrations as it is throughout its postnatal development. Its concentration increases to a peak at the time when rat pups open their eyes and remains at a high level. It is mainly localized to the pigment epithelium, but also to some few neurons of varying types in the inner retina. Cystatin C is similarly expressed in normal mouse and human retinas. Cystatin C is in the anterior segment of normal rat and mouse eyes. Cysteine proteases play an important role in protein degradation (e.g. of photoreceptor outer segments in the retinal pigment epithelium) and the balance between these proteases and their specific inhibitors is therefore of great interest. Cystatin C level is increased in patients with malignant diseases, rheumatic diseases and related to the insufficiency of renal function. This protein appears to be a better marker than creatine. It may be especially useful in those cases where the creatinine measurement is not appropriate: for instance in liver cirrhosis, an obese, in malnourished or in patients with reduced muscle mass, too. Cystatin C measurement may also be useful in the early detection of kidney disease when other parameters might still be normal, especially in the elderly. In addition to kidney dysfunction, it has been associated with an increased risk of cardiovascular disease and heart failure in older *****s. Researches are exploring other uses of Cystatin C, and the reasons for doctors ordering they may evolve over time. Low levels of Cystatin C indicate cause the breakdown of the elastic laminae and, subsequently, the atherosclerosis and abdominal aortic aneurysm. The blood level of Cystatin C predicts survival after one type of heart attack. On the other hand, a high level of Cystatin C in the blood after a heart attack is an ominous sign because it reflects the failure of kidney to clear Cystatin C from the blood into the urine. A mutation of the Cystatin C gene is responsible for a type of amyloidosis in which deposits in the brain result in premature strokes, intracranial hemorrhage, and dementia. This disease is called amyloidosis VI or cerebroarterial amyloidosis. It is inherited in an autosomal dominant manner. 上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于國內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個國家近五十萬種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對生物化學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認(rèn)知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。
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