產(chǎn)品名稱：TGF beta-2 ELISA
產(chǎn)    地：Demeditec 
產(chǎn)品貨號：DE2396
產(chǎn)品規(guī)格：96 Tests
產(chǎn)品說明：
Special remarks:
Intended Use
The DEMEDITEC TGF?β2 ELISA is an enzyme immunoassay for the quantitative in vitro diagnostic measurement of TGF?β2 in serum, plasma and cell culture supernatant.
Summary and Explanation
Transforming growth factor-β (TGF?β) is a multipotent Cytokine with cell- and dose-dependent activities. This molecule is produced by a number of cells and tissue types, e.g. thrombocytes, bone tissue, placenta and kidneys.
TGF-β2 is not produced by blood platelets, contrary to TGF?β1. This potent Cytokine modulates embryonic development, bone formation, mammary development, wound healing, hematopoiesis, cell cycle progression and the production of the extracellcular matrix.
TGF?β2 – null mice were shown to exhibit perinatal mortality and a wide range of developmental defects for a single gene description which include cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenitial defects.
TGF?β2 has been shown to be a potent growth inhibit factor in the regulation of postnatal cerebellar neurons and neuroblast proliferation. TGF?β2 has been detected in tear fluid.
TGF?β2 levels are elevated in the vitreous of patients with proliferative diabetic retinopathy. Elevated plasma levels of TGF?β2 have been described in patients with disseminated malignant melanoma.
TGF?β2 concentrations are furthermore elevated in Parkinson’s disease in ventricular cerebrospinal fluid.
Principle of the test
The DEMEDITEC TGF?β2 ELISA Kit is a solid phase enzyme-linked immunosorbent assay (ELISA) based on the sandwich principle.
Prior to testing the standards and patient samples are diluted in assay buffer, acidified with HCl and then neutralized with NaOH.
Afterwards, the neutralized standards and samples are added to the antibody coated (polyclonal) microtiter wells. After the first incubation the unbound sample material is removed by washing. Then a biotinilated mouse anti TGF-β2 antibody and the Streptavidin-HRP Enzyme complex are incubated in succession. An immuno enzyme sandwich complex is formed.
After incubation the unbound conjugate is washed off. Having added the substrate solution, the intensity of colour developed is proportional to the concentration of TGF?β2 in the patient sample.
上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于國內(nèi)**地位，公司提供的產(chǎn)品涵蓋了二十多個(gè)國家近五十萬種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對生物化學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認(rèn)知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。

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