產品名稱：TSH 1h IRMA
產    地：Demeditec
產品貨號：DE15100
產品規(guī)格：100 Tests
產品說明：
Special remarks: Thyroid-stimulating hormone (TSH) or human thyrotropin is a glycoprotein hormone of approximate molecular weight of 28,000 Da, secreted by thyreotrope cells of the anterior pituitary gland. hTSH is composed of two non covalently bound distinct subunits designated  a and b.The a-subunit is common to the other glycoprotein hormones:  follicle stimulating hormone (hFSH), luteinizing hormone (hLH) and chorionic gonadotropin (hCG). The beta-subunit determines both the biological and immunological  specificity and allows the recognition and the differentiation of hTSH from other glycoprotein hormones by the antibody.
The main function of hTSH is the regulation of synthesis and release  of the thyroid hormones. The secretion and the liberation of hTSH are stimulated by the hypothalamic tripeptide TRH (TSH-Releasing Hormone) and are controlled by serum concentrations of the thyroid hormones:  thyroxine (T4) and triiodthyronine (T3) through a negative feedback mechanism: in the thyreotrope cells, T4 is desiodinated in T3 which directly inhibits hTSH secretion.
When the hypothalamo-hypophyso-thyroid axis is normal, thyroid hormone insufficiency is associated with a response of the thyreoprope cells to TRH, and an increased secretion of hTSH. In contrast, when thyroid  hormones are available in excess, response to TRH is reduced and hTSH  secretion is suppressed. Hypothyroidism  and hyperthyroidism are associated with pathologies if diverse origins of the hypothalamo-hypophyso-thyroid axis, reflected by the concentrations in hTSH, thyroid hormones, and the hTSH response to the exogenous TRH test.
Until now, hTSH measurement was the most sensitive indicator for the diagnosis of primary hypothyroidism with an increased secretion of hTSH and a decrease of thyroid hormone concentrations.
Today, the use of monoclonal antibodies increases the sensitivity of the test
by immunoradiometric sandwich assay and allows a better discrimination
between hyperthyroid and euthyroid population with a decrease in the level.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于國內**地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數(shù)量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫(yī)學領域的應用。

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