產(chǎn)品名稱：Geldanamycin 產(chǎn)品貨號(hào)：Affix AF3044 產(chǎn)品規(guī)格：1 mg Technical Data Chemical Name 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate Biological Description Geldanamycin is a benzoquinone ansamycin antibiotic that selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity.Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90. Molecular Weight 560.6 daltons Molecular Formula C29H40N2O9 Solubility Soluble in DMSO (10 mg/ml) Purity >98% Storage instructions Up to one week at 4°C or six months at -20°C. CAS No. 30562-34-6 References Koga, F., et al. 2007. Cell Cycle. 6: 1393-1402.
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