產(chǎn)品名稱：Gefitinib 產(chǎn)品貨號(hào)：Affix AF3034 產(chǎn)品規(guī)格：100 mg Technical Data Chemical Name N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine Biological Description Gefitinib is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and has been shown to increase phosphorylation of c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in HaCaT cells. The Gefitinib selective inhibitor of EGFR tyrosine kinase (IC50 = 23 - 79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice. Molecular Weight 446.9 daltons. Molecular Formula C22H24CIFN4O3 Solubility Soluble in DMSO, up to about (100 mg/mL) Not soluble in water or ethanol. Purity >98% Storage instructions Up to one week at 4°C or six months at -20°C. CAS No. 184475-35-2 References Lu, P.H., et al. 2010. Br J Dermatol.
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