產(chǎn)品名稱：Dasatinib 產(chǎn)品貨號(hào)：Affix AF3033 產(chǎn)品規(guī)格：100 mg Technical Data Chemical Name N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-Thiazolecarboxamide Biological Description Dasatinib is a potent inhibitor of imatinib-resistant KIT activation loop mutants and induces apoptosis in mast cell and leukemic cell lines expressing these mutations. Dasatinib sensitively inhibits all members of the Src family, including c-Src, Lck,Fyn, and Yes (IC50 < 1.1nmol/L). At higher concentrations (3 to 28 nmol/L), dasatinib also inhibits the Src kinases Abl, c-Kit, PDGFR, and EphA2. Molecular Weight 506.0 daltons. Molecular Formula C22H28CIN7O3S Solubility Soluble in DMSO (200 mg/mL), Not soluble in ethanol and water. Purity >97% Storage instructions Up to one week at 4°C or six months at -20°C. CAS No. 302962-49-8 References Talpaz, M., et al. 2006. N. Engl. J. Med. 354: 2531-2541.
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