Tyrphostin AG 1478, Free Base **
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產(chǎn)品名稱: Tyrphostin AG 1478, Free Base **
產(chǎn)品型號(hào): LC T-7310
產(chǎn)品展商: 原裝進(jìn)口
產(chǎn)品文檔: 無(wú)相關(guān)文檔
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Tyrphostin AG 1478, Free Base **
Tyrphostin AG 1478, Free Base **
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Tyrphostin AG 1478, Free Base **
產(chǎn)品名稱：Tyrphostin AG 1478, Free Base
產(chǎn)品貨號(hào)：LC T-7310
產(chǎn)品規(guī)格：1 G
Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 µM). Osherov, N. and Levitzki, A. "Epidermal-growth-factor-dependent activation of the src-family kinases." Eur. J. Biochem. 225: 1047-1053 (1994). Levitzki, A. and Gazit, A. "Tyrosine kinase inhibition: an approach to drug development." Science 267: 1782-1788 (1995).
Reversibly inhibits (IC50 = 9.8 µM) the rat brain Kv1.5 potassium channel in vitro in a non-protein-tyrosine-kinase-mediated manner. Choi, B.H., et al. "Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor." Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002).
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 50 mg/mL; soluble in ethanol at 25 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Appearance: White solid. Disposal: A
