產(chǎn)品名稱：Thapsigargin 產(chǎn)品貨號：LC T-3250 產(chǎn)品規(guī)格：10 MG Potent, cell permeable IP3-independent intracellular calcium releaser. Takemura, H., et al. "Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane." J. Biol. Chem. 264: 12266-12271 (1989). Inhibits microsomal Ca2+-ATPase. Thastrup, O., et al. "Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage." Agents Actions 27: 17-23 (1989). Rat mast cell histamine secretagogue. Rasmussen, U.S.B., et al. "Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica" Acta Pharm. Suecica 15: 133-140 (1978). Patkar, S.A., et al. "On the mechanism of histamine release induced by thapsigargin from Thapsia garganica L." Agents Actions 9: 53-57 (1979). Mouse skin tumor promoter with potency somewhat weaker than teleocidin or PMA, but does not bind to protein kinase C or induce ornithine decarboxylase activity. Hakii, H., et al. "Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis." J. Cancer Res. Clin. Oncol. 111: 177-181 (1986). Stimulates arachidonic acid metabolism in macrophages. Ohuchi, K., et al. "Stimulation of arachidonic acid metabolism in rat peritoneal macrophages by thapsigargin, a non-(12-O-tetradecanoylphorbol-13-acetate) (TPA)-type tumor promoter." J. Cancer Res. Clin. Oncol. 113: 319-324 (1987). WARNING: Highly irritant to skin and mucous membranes. SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure. Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A
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