產(chǎn)品名稱：Leptomycin B 產(chǎn)品貨號：LKT L1761 產(chǎn)品規(guī)格：1µg Description Leptomycin B (LepB) is an antifungal antibiotic, found to be a potent antitumor agent. It is suggested that the antitumor effect is related to cytochrome c release, activation of caspases, and selective down-regulation ofMc1-1 and XIAP. Leptomycin B has Specifications Cas No. 87081-35-4 Product ID L1761 Product Name Leptomycin B Chemical Name 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo- 2,10,12,16,18-Nonadecapentaenoic acid Synonym LMB; Elactocin, CI-940, CL-1957A, NSC-364372, PD-114720. Formula Wt. 540.74 Melting Point 41oC-44oC Purity ≥98% Solubility Soluble in ethanol or methanol. Stability WARNING: Small quantities of LepB are reported to be unstable when dried down into a film. Thus, under no circumstances should the solvent be removed from solutions of LepB, because rapid decomposition may result. Store Temp -20oC References Sasaki H, Yoshida M, Beppu T. Radiat Res. 129:163-70 (1992). Jang BC, Paik JH, Jeong HY et al. Biochem Pharmacol. 68:263-74 (2004). Meissner T, Krause E, Vinkemeier U. FEBS Lett. 576:27-30 (2004).Fukuda.M., et al Nature 390:308-311 (1997). Kudo, N.
滬公網(wǎng)安備 31011002002623號
