產(chǎn)品名稱：Mouse IL-17E (IL-25) ELISA Ready-SET-Go! 2 plates 產(chǎn)品貨號(hào)：eBioscience 88-7002-22 產(chǎn)品規(guī)格：2 x 96 tests w/plates Mouse IL-17E (IL-25) ELISA Ready-SET-Go!® Also known as: Interleukin-17E, Interleukin-25 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 88-7002 Cat. No. Size 88-7002-22 2 x 96 tests w/plates 88-7002-86 10 x 96 tests w/plates 88-7002-88 10 x 96 tests Description: This Mouse IL-17E ELISA Ready-SET-Go! reagent set contains all of the necessary buffers and reagents to perform enzyme-linked immunosorbent assays. The set has been optimized for the accurate and precise measurement of mouse IL-17E in serum, plasma, and tissue culture supernatant samples. Serum and plasma samples must be diluted 8-fold in the provided sample diluent prior to evaluation in this assay. IL-17E, or IL-25, was first identified as an IL-17 family member on the basis of sequence homology. It was originally believed to be a Th2 cytokine based on the detection of mRNA transcripts in polarized Th2 cells, but expression was later observed in epithelial cells, eosinophils, and mast cells. Later studies confirmed the role of IL-17E as a potent inducer of type 2 immune responses. IL-17E signaling induces the differentiation of CD4+ T cells towards the Th2 lineage and upregulates expression of Th2 cytokines such as IL-4, IL-5, and IL-13. Administration of IL-17E also promotes symptoms of allergic asthma, such as eosinophil infiltration, airway hyperreactivity, and high circulating levels of IgE. IL-17E binds to IL-17BR, a receptor shared with IL-17B, and activates NF kappa-B pathways.
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