產(chǎn)品名稱：phospho-CREB (Ser133) InstantOne™ ELISA 產(chǎn)品貨號：eBioscience 85-86152-11 產(chǎn)品規(guī)格：96 tests phospho-CREB (Ser133) InstantOne™ ELISA Also known as: Cyclic AMP-responsive element-binding protein RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 85-86152 Cat. No. Size 85-86152-11 96 tests Description: The InstantOne™ ELISA is specifically engineered for accurate measurement of phosphorylated human, mouse, and hamster CREB (Ser133) in cell lysates. Detection of phosphorylated rat CREB (Ser133) is also expected. The InstantOne™ ELISA kit allows for fast analysis of samples in approximately one hour. All reagents used in a traditional sandwich ELISA are added in solution to a plate followed by a wash step and detection with the TMB colorimetric substrate. cAMP response element-binding protein (CREB) is a transcription factor that regulates the expression of numerous genes in response to growth factors, hormones, neurotransmitters, ion fluxes, and stress signals. CREB can form homo- or heterodimers with related family members such as ATF. Upon ligand binding, CREB is activated via phosphorylation at Ser133 by several different kinases, including MAPK and PKA (cAMP-dependent protein kinase). In its inactive form, PKA resides in the cytoplasm as a heterotetramer of paired regulatory and catalytic subunits. Stimulation of cAMP causes release of the catalytic subunits from PKA, thereby allowing phosphorylation of CREB at Ser133.
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