Alexa488 Pan-cytokeratin (clones AE1/AE3), **
產(chǎn)品名稱：Alexa488 Pan-cytokeratin (clones AE1/AE3), 100 ug
產(chǎn)品貨號：eBioscience 53-9003-82
產(chǎn)品規(guī)格：100 ug
Anti-Pan-Cytokeratin (AE1/AE3) Alexa Fluor® 488
Also known as: keratin, basic, acidic
Clone: AE1/AE3
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 53-9003
Cat. No. Size
53-9003-80 25 ug
53-9003-82 100 ug
Description: The monoclonal antibodies AE1 and AE3 recognize many of the acidic and basic cytokeratin family members. Cytokeratins are intermediate filament proteins comprising one component of the cytoskeleton. There are two large families of cytokeratins, acidic and basic, but all contain the same basic domains (i.e. an α-helical core with an N- and C-terminal domain). The proteins are expressed in epithelial cells, but are developmentally regulated. Many tumors also express these proteins and their expression can help identify the origin of a neoplasm.
The AE3 monoclonal antibody recognizes the 65 to 67 triplet, 64, 59, 58, 56, and 52kD proteins also known as cytokeratin 1, 2, 3, 4, 5, 6, 7) while the AE1 antibody recognizes 56.5, 50, 50’, 48, and 40 kDa proteins (also known as CK10, 14, 15, 16 and 19). These antibodies can be used on a wide array of tissue samples from mouse, human, rat, primates (cynomolgus and rhesus), dog, cat, rabbit, and chicken.
