產(chǎn)品名稱：Anti-Human CD221 (Insulin-like Growth Factor-1 Receptor) (clone 1H7) Alexa Fluor® 488, 100 tests 產(chǎn)品貨號：eBioscience 53-8849-42 產(chǎn)品規(guī)格：100 tests Anti-Human CD221 (Insulin-like Growth Factor-1 Receptor) Alexa Fluor® 488 Also known as: IGF1R Clone: 1H7 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 53-8849 Cat. No. Size 53-8849-41 25 tests 53-8849-42 100 tests Description: This 1H7 monoclonal antibody reacts with human insulin-like growth factor-1 receptor (IGF-1R), also known as CD221. This receptor is a cell surface-expressed glycoprotein composed of two extracellular alpha subunits and two transmembrane beta subunits that possess tyrosine kinase activity. Expressed on nearly all cell types, this receptor binds IGF-I and IGF-II, as well as insulin. Ligand binding leads to activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells display altered IGF-1R expression. This monoclonal antibody has been reported to block binding of IGF-I and IGF-II to the IGF-1R.
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