產(chǎn)品名稱：Alexa 488 Anti-Myogenin (clone F5D), 100 ug 產(chǎn)品貨號：eBioscience 53-5643-82 產(chǎn)品規(guī)格：100 ug Anti-Myogenin Alexa Fluor® 488 Also known as: MYOG Clone: F5D RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 53-5643 Cat. No. Size 53-5643-80 25 ug 53-5643-82 100 ug Description: This F5D monoclonal antibody reacts with human, mouse, dog, and rat myogenin, a 34-kDa transcription factor. Expressed in skeletal and heart muscle, myogenin is a member of the MyoD family of basic-helix-loop-helix proteins, which also includes MyoD, Myf5, and MRF4. This transcription factor interacts with other helix-loop-helix proteins, which may or may not be muscle-specific. Myogenin plays a significant role in myogenic differentiation, even directing nonmuscle cells to the myogenic lineage. Transforming growth factor-beta (TGFb) and bone morphogenetic protein-2 (BMP2) inhibit myogenin transcriptional activity. Predominantly residing within the nucleus, the subcellular localization of myogenin has been shown to be dependent on differentiation status and cell density. For instance, trafficking of myogenin between the nucleus and cytoplasm has been reported during skeletal muscle differentiation to mediate transcription control.
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