產(chǎn)品名稱：Alexa Fluor® 488 anti-human CD317 (BST2) 100 tests 產(chǎn)品貨號(hào)：eBioscience 53-3179-42 產(chǎn)品規(guī)格：100 tests Anti-Human CD317 (BST2, PDCA-1) Alexa Fluor® 488 Also known as: plasmacytoid DC Ag-1, pDC Ag-1, BST 2, PDCA1 Clone: 26F8 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 53-3179 Cat. No. Size 53-3179-41 25 tests 53-3179-42 100 tests Description: This 26F8 monoclonal antibody reacts with human CD317 (also known as BST2 and tetherin). CD317 is a 30-36-kDa type II transmembrane protein expressed on B cells and bone marrow stromal cells. Although reports have indicated that CD317 mRNA is detectable in activated T cells, protein expression in freshly isolated primary T cells and macrophages is undetectable. Moreover, certain T cell lines, such as Jurkat, do not express detectable levels of CD317 protein. However, CD317 expression can be induced in many cell types (e.g., T and B cells, 293T, and HeLa) by IFNα treatment. CD317 has been associated with pre-B cell growth and the terminal differentiation of plasma B cells. More recently, this molecule has been reported to prevent HIV-1 virion release from the surface of infected cells, leading to reuptake and degradation of the virus. This activity is inhibited by the HIV-1 accessory protein Vpu. CD317 has been identified as the ligand for the ILT7 receptor.
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