anti-mouse CXCR4 (CD184, Fusin) Alexa Fluor® 647 2B11 **
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產(chǎn)品名稱(chēng): anti-mouse CXCR4 (CD184, Fusin) Alexa Fluor® 647 2B11 **
產(chǎn)品型號(hào): 17-9991-82
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anti-mouse CXCR4 (CD184, Fusin) Alexa Fluor® 647 2B11 **
anti-mouse CXCR4 (CD184, Fusin) Alexa Fluor® 647 2B11 **
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anti-mouse CXCR4 (CD184, Fusin) Alexa Fluor® 647 2B11 **
產(chǎn)品名稱(chēng)：anti-mouse CXCR4 (CD184, Fusin) Alexa Fluor® 647 2B11 100 ug
產(chǎn)品貨號(hào)：eBioscience 17-9991-82
產(chǎn)品規(guī)格：100 ug
Anti-Mouse CD184 (CXCR4) APC
Also known as: Fusin
Clone: 2B11
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 17-9991
Cat. No. Size
17-9991-80 25 ug
17-9991-82 100 ug
Description: The 2B11 monoclonal antibody reacts with mouse and human CXCR4, also known as CD184, Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. In addition it has been shown to play a role in lymphocyte migration. The ligand for CXCR4 is SDF1. CXCR4 is required for maintenance of granulocyte progenitors in the bone marrow and essential for B cell development. Expression of CXCR4 is different between mice and human. In the thymus CXCR4 is restricted to CD4+CD8+ cells while in the spleen predominant expression is found on B lymphocytes.
The monoclonal antibody 2B11 recognizes the amino terminus of CXCR4 and has been reported to have functional activity; it does not block SDF1a but causes internalization of the receptor.
