產(chǎn)品名稱：Anti-Mouse/Human Gata-3 (Gata3) Alexa Fluor® 647 (TWAJ) 100 tests 產(chǎn)品貨號(hào)：eBioscience 51-9966-42 產(chǎn)品規(guī)格：100 tests Anti-Human/Mouse Gata-3 Alexa Fluor® 647 (To Be Discontinued. Refer to Replacement Format eFluor® 660, cat. 50-9966) Also known as: Gata3 Clone: TWAJ RUO: For Research Use Only. Not for use in diagnostic procedures. Attention: Refer to replacement format eFluor® 660, Cat. No. 50-9966 SKU# 51-9966 Cat. No. Size 51-9966-41 25 tests 51-9966-42 100 tests Description: The monoclonal antibody TWAJ recognizes mouse and human Gata-3, a member of the Gata family of transcription factors. Gata-3 is a T cell-specific transcription factor important for thymic development and Th2 differentiation. Expression during embryonic development is found in the central nervous system, skin, mammary glands and kidney. During development, the expression of Gata-3 is essential as homozygous knock-out of Gata-3 is embryonic lethal. The Gata-3 is also essential for T cell commitment and survival. In the thymus, expression is found mainly on the CD4 single positive cells. During Th2 differentiation, Gata-3 binds to the IL-4 promoter as well as represses the expression of T-bet, thus inhibiting Th1 differentiation. Alternative splice variants have been reported especially in the MCF7 cell line. The TWAJ anti-mouse/human Gata-3 antibody will recognize both forms (50 and 45 kDa) of the protein. Staining with the TWAJ anti-mouse/human Gata-3 antibody requires the use of the Foxp3 Staining Buffer Set.
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