產(chǎn)品名稱：Anti-Helios Alexa Fluor® 647 (22F6) 100 ug 產(chǎn)品貨號(hào)：eBioscience 51-9883-82 產(chǎn)品規(guī)格：100 ug Anti-Helios Alexa Fluor® 647 Also known as: Ikaros family zinc finger 2, IKZF2 Clone: 22F6 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 51-9883 Cat. No. Size 51-9883-80 25 ug 51-9883-82 100 ug Description: This 22F6 monoclonal antibody reacts with human, mouse and canine Helios. Helios is a zinc-finger transcription factor first identified for its similarity to Ikaros. It is expressed in hematopoietic stem cells in both the embryo and ***** mice. While the highest expression is found in regulatory T cells, Helios is not expressed in mature B cells, dendritic cells or myeloid cells. Helios can form a homodimer as well as heterodimerize with other Ikaros family members to regulate transcription. Eight isoforms of Helios exist, some of which possess a dominant-negative function that has also been found to be upregulated in lymphoid malignancies, including T-acute lymphoblastic leukemia.
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