產(chǎn)品名稱：anti-mouse Granzyme B Alexa Fluor® 647 16G6 25 ug 產(chǎn)品貨號(hào)：eBioscience 51-8822-80 產(chǎn)品規(guī)格：25 ug Anti-Mouse Granzyme B Alexa Fluor® 647 (To Be Discontinued. Refer to Alternative Product Catalog number 51-8898) Also known as: GrzB, GrB Clone: 16G6 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 51-8822 Cat. No. Size 51-8822-80 25 ug Description: The 16G6 antibody reacts with mouse Granzyme B (GrB) which is a member of the granzyme serine protease family. GrB is found in the granules of cytotoxic T cells and NK cells. Granzyme B has also been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation. GrB has been called CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. GrB is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. For intracellular staining and flow cytometric analysis with direct conjugates of anti-mouse Granzyme B, it is highly recommended to use the Foxp3 Staining Buffer Set (cat. 00-5523). Other buffers may yield varying results. For more information, please contact technical support at tech@ebioscience.com.
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