產(chǎn)品名稱：Alexa647 Mouse IL-21 (clone mhalx21), 25 ug 產(chǎn)品貨號：eBioscience 51-7213-80 產(chǎn)品規(guī)格：25 ug Anti-Mouse IL-21 Alexa Fluor® 647 (To Be Discontinued. Refer to Cat. No. 50-7213) Also known as: Interleukin-21 Clone: mhalx21 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 51-7213 Cat. No. Size 51-7213-80 25 ug Description: The monoclonal antibody mhalx21 reacts with mouse interleukin-21 (IL-21). IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by NKT, T helper (Th) 17 and T follicular helper (Tfh) cells. In Tfh cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1, IL-4 for Th2 and IL-17A for Th17, IL-21 is critical for Tfh cell effector function. This cytokine plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naïve B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. High levels of IL-21 are present in chemically-induced colitis models. IL-21-deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. Preliminary data suggest that clone mhalx21 recognizes a different epitope than anti-mouse IL-21 clone FFA21 (cat. 51-7211).
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