產(chǎn)品名稱：Anti-Mouse AIRE Alexa Fluor® 647 (5H12) 100 ug 產(chǎn)品貨號(hào)：eBioscience 51-5934-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse AIRE Alexa Fluor® 647 Also known as: Autoimmune Regulator Clone: 5H12 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 51-5934 Cat. No. Size 51-5934-80 25 ug 51-5934-82 100 ug Description: This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE). This 58-kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation. The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2.
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