anti-mouse/human OCT3/4, Pou5f1, transcription factor 1 Alexa Fluor® 647 E
如果您對該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: anti-mouse/human OCT3/4, Pou5f1, transcription factor 1 Alexa Fluor® 647 E
產(chǎn)品型號(hào): 51-5841-82
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
anti-mouse/human OCT3/4, Pou5f1, transcription factor 1 Alexa Fluor® 647 EM92**
anti-mouse/human OCT3/4, Pou5f1, transcription factor 1 Alexa Fluor® 647 E
的詳細(xì)介紹
anti-mouse/human OCT3/4, Pou5f1, transcription factor 1 Alexa Fluor® 647 EM92**
產(chǎn)品名稱：anti-mouse/human OCT3/4, Pou5f1, transcription factor 1 Alexa Fluor® 647 EM92 100 ug
產(chǎn)品貨號(hào)：eBioscience 51-5841-82
產(chǎn)品規(guī)格：100 ug
Anti-Human/Mouse OCT3/4 Alexa Fluor® 647 (To Be Discontinued. See Cat. No. 50-5841)
Also known as: OCT3, OCT4, octamer-binding transcription factor, POU5F1
Clone: EM92
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 51-5841
Cat. No. Size
51-5841-80 25 ug
51-5841-82 100 ug
Description: The EM92 monoclonal antibody reacts with mouse and human Oct-3/4, encoded by the Pou5F1 gene. Oct-3/4 is a POU domain-containing transcription factor that is critical for maintaining embryonic stem (ES) and induced pluripotent stem (iPS) cells in a pluripotent state, and is expressed by ES, embryonic germ cells and embryonic carcinoma cell lines. In cells of the inner cell mass (ICM), reduction of Oct-3/4 expression causes dedifferentiation to trophoectoderm, whereas increased expression results in differentiation to mesoderm and primitive endoderm. Oct-3/4 regulates the expression of several genes, including FGF-4, UTF1, Sox2, Fbx15, Rex1 and osteopontin through distinct mechanisms. Furthermore, Oct-3/4 frequently acts synergistically with Sox2 to regulate target gene expression, as is the case with FGF-4. It has been demonstrated that Oct-3/4 expression in ES cells can be negatively regulated by either treatment with retinoic acid, or by removal of leukemia-inhibitory factor (LIF).
