產(chǎn)品名稱：anti-mouse Ly49D Alexa Fluor® 647 eBio4E5 (4E5) 25 ug 產(chǎn)品貨號：eBioscience 51-5782-80 產(chǎn)品規(guī)格：25 ug Anti-Mouse Ly-49D Alexa Fluor® 647 (Discontinued; refer to Cat. No. 17-5782) Also known as: Ly49D Clone: eBio4E5 (4E5) RUO: For Research Use Only. Not for use in diagnostic procedures. Attention: Alternative format APC, Cat. No. 17-5782 SKU# 51-5782 Description: The monoclonal antibody eBio4E5 (4E5) reacts with Ly-49D, an activating member of the Ly-49 family of NK cell receptors. This family of receptors form homodimers that recognize MHC Class I molecules. The activating Ly-49 receptors (Ly-49D and Ly-49H) do not contain immune receptor tyrosine-based inhibitory motifs (ITIM) in their cytoplasmic domains, distinguishing them from the inhibitory Ly-49 family members. Instead, activating Ly-49 molecules have been shown to associate with DAP12 which contains an immunoreceptor tyrosine-based activation motif (ITAM) that is required for positive signaling. Expression of different Ly-49 family members is not linked, therefore, several Ly-49 proteins can be expressed on the same cells. Expression of Ly-49D on subsets of NK cells is strain-dependent and is found in C57BL/6, CB6F1 and SJL mice, while BALB/c, DBA/2, AKR and CBA/J mice are negative for Ly-49D. In 129/J mice, eBio4E5 also recognizes Ly-49O, Ly-49V and Ly-49R. eBio4E5 is reported to have functional (activating) activity.
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