產(chǎn)品名稱：anti-mouse NKp46 (CD335) Alexa Fluor® 647 29A1.4 100 ug 產(chǎn)品貨號：eBioscience 51-3351-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse CD335 (NKp46) Alexa Fluor® 647 (To Be Discontinued. Refer to Replacement Format eFluor® 660, cat. 50-3351) Also known as: NCR1, Ly-94, Ly94 Clone: 29A1.4 RUO: For Research Use Only. Not for use in diagnostic procedures. Attention: To Be Discontinued. Refer to Replacement Format eFluor® 660 cat. 50-3351 SKU# 51-3351 Cat. No. Size 51-3351-80 25 ug 51-3351-82 100 ug Description: The monoclonal antibody 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines. The 29A1.4 monoclonal antibody has been shown to activate NK cells in vitro. The 29A1.4 monoclonal antibody does not deplete NK cells in vivo.
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