Alexa 647 Human/mouse beta-catenin (clone 15B8), **
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產(chǎn)品名稱(chēng): Alexa 647 Human/mouse beta-catenin (clone 15B8), **
產(chǎn)品型號(hào): 51-2567-42
產(chǎn)品展商: 其他品牌
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Alexa 647 Human/mouse beta-catenin (clone 15B8), **
Alexa 647 Human/mouse beta-catenin (clone 15B8), **
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Alexa 647 Human/mouse beta-catenin (clone 15B8), **
產(chǎn)品名稱(chēng)：Alexa 647 Human/mouse beta-catenin (clone 15B8), 100 tests
產(chǎn)品貨號(hào)：eBioscience 51-2567-42
產(chǎn)品規(guī)格：100 tests
Anti-Human/Mouse beta-Catenin Alexa Fluor® 647 (To Be Discontinued. Refer to Cat. No. 50-2567)
Also known as: b-catenin, catenin b
Clone: 15B8
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 51-2567
Cat. No. Size
51-2567-41 25 tests
51-2567-42 100 tests
Description: The 15B8 monoclonal antibody reacts with human and mouse beta-catenin, one member of a family of catenins, which are intracellular proteins that interact with cadherins to mediate cellular adhesion. More specifically, beta-catenin binds to the cytoplasmic tail of E-cadherin. In addition, this molecule is a component of the canonical Wnt signaling pathway. In the absence of Wnt binding its receptor, beta-catenin is phosphorylated and resides in the cytoplasm where it is eventually targeted for degradation by ubiquitination. Upon Wnt binding, beta-catenin becomes dephosphorylated, translocates to the nucleus, and modulates gene expression in partnership with the transcription factors T cell factor (TCF) and lymphocyte enhancer binding factor (LEF). Expression of beta-catenin is found in a wide variety of non-immune and immune tissues, including thymocytes and T and B lymphocytes. The Wnt & beta-catenin signaling pathway has been demonstrated to play a crucial role in the development of T, B, and hematopoietic stem cells.
