產(chǎn)品名稱：Alexa 647 Mouse CD226 (clone 10E5), 100 ug 產(chǎn)品貨號：eBioscience 51-2261-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse CD226 (DNAM-1) Alexa Fluor® 647 (To Be Discontinued. See Cat. No. 17-2261) Also known as: DNAM1, PTA1, Tlisa Clone: 10E5 RUO: For Research Use Only. Not for use in diagnostic procedures. Attention: Replacement format is APC. Select Cat. No. 17-2261. SKU# 51-2261 Cat. No. Size 51-2261-80 25 ug 51-2261-82 100 ug Description: This 10E5 monoclonal antibody reacts with mouse CD226, which is also known as DNAX accessory molecule-1 (DNAM-1). CD226 is an adhesion molecule expressed primarily on T cells, including thymocytes. The highest levels of CD226 are found on naïve CD8 T cells. Moreover, expression of CD226 is regulated differentially in CD4 T cells. Under certain culture conditions, CD226 can be upregulated in Th1 and downregulated in Th2 and Th0 cells. This cell surface receptor can also be detected on natural killer cells, some B cell subsets, monocytes, and platelets. Interaction with its ligands, the poliovirus receptor (CD155) and CD112, results in adhesion and cell signaling events that promote innate and adaptive immunity, including differentiation, survival, and cytotoxicity. The 10E5 monoclonal antibody has been reported to inhibit antigen-specific T cell proliferation and IFN-gamma production in vivo.
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