產(chǎn)品名稱(chēng)：anti-mouse SIGN-R1 Alexa Fluor® 647 eBio22D1 (22D1) 100 ug 產(chǎn)品貨號(hào)：eBioscience 51-2093-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse CD209b (SIGN-R1) Alexa Fluor® 647 (To be Discontinued. Refer to Cat. No. 17-2093) Also known as: C-type lectin, SIGNR1 Clone: eBio22D1 (22D1) RUO: For Research Use Only. Not for use in diagnostic procedures. Attention: Alternative Format - APC. Cat. No. 17-2093 SKU# 51-2093 Cat. No. Size 51-2093-80 25 ug 51-2093-82 100 ug Description: The eBio22D1 monoclonal antibody reacts with mouse SIGNR1 (CD209b). SIGNR1 is a type II transmembrane C-type lectin that was identified in a search for mouse homologues of human DC-SIGN. It is expressed at high levels in splenic marginal zone macrophages and lymph node medullary macrophages, where it functions to uptake dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae. It has also been demonstrated that SIGNR1 physically associates with TLR4/MD2, and it has been suggested that this association plays a role in recognition of LPS. Furthermore, recently it has been shown that SIGNR1 deficient mice have a defect in catabolism of the complement component C3, and that SIGNR1 binds directly to the complement C1 subcomponent, C1q to assemble a non-conventional C3 convertase. The eBio22D1 monoclonal antibody does not cross-react with the closely related SIGNR1, SIGNR2, SIGNR3 or SIGNR4.
滬公網(wǎng)安備 31011002002623號(hào)
