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產(chǎn)品名稱：anti-mouse CD207 Alexa Fluor® 647 eBioRMUL.2 100 ug 產(chǎn)品貨號：eBioscience 51-2073-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse CD207 (Langerin) Alexa Fluor® 647 (To Be Discontinued. refer to Cat. No. 50-2073) Also known as: CLEC4K Clone: eBioRMUL.2 RUO: For Research Use Only. Not for use in diagnostic procedures. Attention: Replacement format is eFluor 660. Select Cat. No. 50-2073. SKU# 51-2073 Cat. No. Size 51-2073-80 25 ug 51-2073-82 100 ug Description: RMUL.2 is a monoclonal antibody that reacts with the predicted extracellular domain of mouse Langerin (CD207). Mouse Langerin(CD207) is expressed in a distinct subset of Dendritic cells called Langerhans cells (LC). Mouse Langerin is a 48kDa C-type lectin putative transmembrane protein that likely plays a role in antigen recognition and uptake. Langerhans cells are located in the epidermis and upon activation, reduce Langerin expression and begin migrating through the dermis towards lymphatic vessels. Expression of mouse Langerin in LC has been correlated to the presence of Birbeck Granules. Furthermore, the formation of Birbeck Granules has been observed upon transfection of Langerin cDNA into fibroblast cell lines. Western Blotting with RMUL.2 reveals a 48kDa band in lysate from mouse ear epidermis, as well as in lysates from cells transfected with mouse Langerin cDNA. Cross reactivity of this antibody with other proteins has not been determined. Preliminary data from mouse Langerin cDNA transfected cells suggests that RMUL.2 can be used for intracellular flow cytometric analysis. We have observed in our transfectants the majority of protein is expressed intracellularly with a small percentage on the cell surface. In addition, RMUL.2 has also been tested by immunohistology on mouse ear epidermal sheets and shows specific staining when compared to a polyclonal antibody obtained from a different supplier.
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