產品名稱：human IL-23 eFluor 660 (clone: 23dcdp)100 tests 產品貨號：eBioscience 50-7823-42 產品規(guī)格：100 tests Anti-Human IL-23 p19 eFluor® 660 Also known as: Interleukin-23 p19 Clone: 23dcdp RUO: For Research Use Only. Not for use in diagnostic procedures. Attention: eFuor® 660 is a perfect alternative to APC and Alexa Fluor® 647 formats SKU# 50-7823 Cat. No. Size 50-7823-41 25 tests 50-7823-42 100 tests Description: This 23dcdp monoclonal antibody reacts with the p19 subunit of human IL-23. This heterodimeric cytokine is composed of two disulfide-linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. The IL-23 receptor is also heterodimeric and shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to the IL-23 receptor complex. IL-23R signaling occurs through the Jak/STAT pathway and results in RORγt expression, which promotes maintenance and proliferation of T helper 17 (Th17) cells. Dendritic cells and macrophages produce high levels of p40 and low levels of IL-23 in response to TLR2, TLR4, and TLR8 ligands and agonists of the β-glucan receptor, Dectin-1. This is due to the presence of monomer and dimer forms of p40, while only a small portion associates with p19 to form IL-23. Our studies suggest donor variability, expression kinetics and type of stimulant can result in variation in IL-23 expression levels. Recent publications suggest the p19 subunit may also exist in the absence of association with p40.
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