產(chǎn)品名稱：mouse IL-23 p19 eFluor 660 (Clone: fc23cpg) 100 ug 產(chǎn)品貨號：eBioscience 50-7023-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse IL-23 p19 eFluor® 660 Also known as: Interleukin-23 p19 Clone: fc23cpg RUO: For Research Use Only. Not for use in diagnostic procedures. Attention: eFluor® 660 is a perfect alternative for APC and Alexa Fluor® 647 formats SKU# 50-7023 Cat. No. Size 50-7023-80 25 ug 50-7023-82 100 ug Description: This fc23cpg monoclonal antibody reacts with the p19 subunit of mouse IL-23, a heterodimeric cytokine made up of two disulfide-linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. IL-23 signals through a heterodimeric receptor expressed on activated T cells, macrophages, and dendritic cells. The receptor shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to the IL-23 receptor complex. Binding of IL-23 to its receptor activates Jak/STAT pathways similarly to IL-12, but the two cytokines exhibit distinct functions. Unlike IL-12, which induces T-bet and Th1 differentiation, IL-23 signaling results in RORγt expression and supports CD4+ T cells with the Th17 phenotype Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as agonists of the β-glucan receptor, Dectin-1. Our studies suggest donor, kinetics and type of stimulant can result in variation in IL-23 expression levels. Recent publications suggest the p19 subunit may also exist in the absence of association with p40.
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