產(chǎn)品名稱：Anti-Human CD38 (clone HB7) eFluor® 450, 100 tests 產(chǎn)品貨號：eBioscience 48-0388-42 產(chǎn)品規(guī)格：100 tests Anti-Human CD38 eFluor® 450 Also known as: ADP-Ribosyl Cyclase, Cyclic ADP-Ribose Hydrolase Clone: HB7 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 48-0388 Cat. No. Size 48-0388-41 25 tests 48-0388-42 100 tests Description: The HB7 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane protein. CD38 is an ectoenzyme which catalyses NAD into nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR), both of which are secondary messengers. Expression of CD38 is bimodal during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. Additionally CD38 is found in a variety of tissues and other hematopoietic cells (e.g. T cells, NK cells and monocytes) and can be used to phenotype leukemias and monitor HIV-1 progression. The CD34+CD38- population of hematopoietic stems cells is thought to define the most pluripotent cells (e.g. blast colony forming cells). In addition to surface expression, CD38 has recently been found in the nucleus where it may play a role in monitoring calcium levels.
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