產(chǎn)品名稱：anti-mouse IL-22 PerCP-eFluor® 710 (clone: 1H8PWSR) 產(chǎn)品貨號(hào)：eBioscience 46-7221-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse IL-22 PerCP-eFluor® 710 Also known as: Interleukin-22 Clone: 1H8PWSR RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 46-7221 Cat. No. Size 46-7221-80 25 ug 46-7221-82 100 ug Description: The 1H8PWSR monoclonal antibody reacts with mouse interleukin(IL)-22. IL-22 is a 20 kDa member of the IL-10 cytokine family that is secreted primarily by Th17, NK cells, and some other T cells. In in vitro Th17 cultures, induction of IL-22 expression is greater in response to IL-23 than IL-6 or TGF-ß, suggesting that this cytokine may be secreted by more fully differentiated Th17 cells in vivo. A heterodimer consisting of IL-10R2 and IL-22R1 serves as the receptor for IL-22. Th17-secreted IL-22 binds to the IL-22 receptor complexon target cells to induce the expression of anti-microbial peptides ß-defensin-2 and ß-defensin-3. Recently, it was demonstrated that IL-22 is able to protect hosts against bacterial infections of the lungs and gut.
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