產(chǎn)品名稱：Anti-Human c-ErbB3 (HER3) (clone SGP1) PerCP-eFluor 710, 100 tests 產(chǎn)品貨號：eBioscience 46-6555-42 產(chǎn)品規(guī)格：100 tests Anti-Human c-ErbB3/HER3 PerCP-eFluor® 710 Clone: SGP1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 46-6555 Cat. No. Size 46-6555-41 25 tests 46-6555-42 100 tests Description: This SGP1 monoclonal antibody reacts with human c-ErbB3, which is also known as HER3. This epidermal growth factor (EGF) receptor family member is expressed on normal human tissues, particularly on neurons and cells of the gastrointestinal tract. c-ErbB3 is overexpressed in a variety of cancers, including breast, ovary, and gastrointestinal carcinomas. Upon binding its ligand heregulin beta-1, c-ErbB3 is activated by heterodimerization with ErbB2 or EGFR1. Dependent on PI3K signaling, c-ErbB3 mediates tumor cell invasion, intravasation, and metastasis. Expression of this cell surface receptor has been used as a prognostic marker for breast cancer. The SGP1 antibody has been reported to stimulate anchorage-independent growth of breast cancer cell lines.
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