產(chǎn)品名稱：Anti-Human CD85d (ILT4) PerCP-eFluor® 710 (42D1) 100 tests 產(chǎn)品貨號：eBioscience 46-5149-42 產(chǎn)品規(guī)格：100 tests Anti-Human CD85d (ILT4) PerCP-eFluor® 710 Also known as: LIR2, LILRB2, MIR10 Clone: 42D1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 46-5149 Cat. No. Size 46-5149-41 25 tests 46-5149-42 100 tests Description: The monoclonal antibody 42D1 recognizes the CD85d protein also known as ILT4, LIR-2. It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leukocyte Ig-like receptor), MIR (monocytes Ig-like receptor) family. CD85d is a 110 kDa single transmembrane receptor with 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Expression is confined to monocytes, macrophages and dendritic cells. The ligand for CD85d is non-classical class I HLA-G, -B and G1. Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM. Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation. Additionally, it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection. Crosslinking of the receptor with the monoclonal antibody 42D1 inhibits calcium flux as well as enhancing HLA-G tetramer staining and restoring the stimulating activity of tolerogenic DC.
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