產(chǎn)品名稱：Anti-Human CD182 (CXCR2) (clone 5E8-C7-F10) PerCP-eFluor® 710, 100 tests 產(chǎn)品貨號：eBioscience 46-1829-42 產(chǎn)品規(guī)格：100 tests Anti-Human CD182 (CXCR2) PerCP-eFluor® 710 Also known as: C-X-C chemokine receptor type 2, Interleukin-8 Receptor B Clone: ebio5E8-C7-F10 (5E8-C7-F10) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 46-1829 Cat. No. Size 46-1829-41 25 tests 46-1829-42 100 tests Description: The eBio5E8-C7-F10 monoclonal antibody reacts with human CD182 (CXCR2, IL-8R beta). CD182 is a 67-70 kDa member of the seven-transmembrane spanning G-protein coupled receptor (GPCR) family. CD182 is expressed as a homodimer, or a heterodimer with CD181 (CXCR1, IL-8R alpha) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO alpha, -beta and -gamma, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.
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