產(chǎn)品名稱：Anti-Human/Non-Human Primate CD16 PerCP-eFluor® 710 (3G8) 100 tests 產(chǎn)品貨號：eBioscience 46-0166-42 產(chǎn)品規(guī)格：100 tests Anti-Human/Non-Human Primate CD16 PerCP-eFluor® 710 Also known as: FcgRIII, FcgR3, ADCC receptor Clone: 3G8 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 46-0166 Cat. No. Size 46-0166-41 25 tests 46-0166-42 100 tests Description: This 3G8 monoclonal antibody reacts with human and non-human primate CD16, which is also known as the low-affinity FcγRIII. CD16 exists as two distinct isoforms, FcγRIIIA and FcγRIIIB. In humans, FcγRIIIA is expressed as a polypeptide-anchored form on monocytes, macrophages, and lymphocytes such as NK cells. T and B cells do not express this Fc receptor. FcγRIIIB is also detected on neutrophils as a GPI-anchored form. Expression of CD16 on lymphocytes and monocytes is similar in non-human primates. However, while CD16 is not found on neutrophils in macaques and baboons, this receptor is detected on these cells in sooty mangabeys. Binding of IgG leads to activation of signal transduction pathways, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, cytokine release, and antigen presentation. This monoclonal antibody has been reported to have several functional activities, including inhibition of cytotoxic ability, activation of cell signaling, and NK cell depletion in vivo. Moreover, the 3G8 antibody clone has been demonstrated to work on capuchin monkey, chimpanzee, common marmoset, cynomologous monkey, hamadyras baboon, olive baboon, pigtailed macaque, rhesus, and squirrel monkey. Based on cross-blocking studies 3G8 recognizes the same epitope as CB16. However, 3G8 and B73.1 antibody clones bind distinct epitopes.
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